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PhD for research in anti-inflammatory properties of hematopoietic stem cells
PhD for research in anti-inflammatory properties of hematopoietic stem cells
Anti-inflammatory properties of hematopoietic stem cells- Closing date 18-02-2026
- 2648
- 36 hours
- Research university
- Closing date 18-02-2026
- 2648
Job description
Inflammation of extended criteria donor livers after transplant results in complications for the recipient. Therefore we want to reduce inflammation of these livers. One of the windows where we can manipulate donor livers is during organ perfusion. Organ perfusion is currently performed with oxygenated perfusate. We want to add human hematopoietic stem cells (HSC; CD34+ derived from the recipient) to the machine perfusion to reduce liver inflammation.
The project you will be working on is at the intersection between Hematology and immunology. This project entails the detailed characterization of HSCs from healthy donors and the functionality of the cells HSCs differentiate into. You will culture HSCs and functionally characterize these longitudinally using RNAsequencing, flowcytometry, mass spectrometry, ELISA. You will determine their anti-inflammatory properties by performing co-culture experiments. Next, you will determine wheter HSC obtained from patient with end-stage liver failure have the same characteristics. The endgoal of this project is to optimize the HSC culture to improve liver regeneration and reduce inflammation
Work environment
The Erasmus MC, has a position for a PhD-student in the field of immunobiology of the hematopoietic system. This project is a collaboration between the department of Internal Medicine and Hematology. The PhD position will be conducted within the research school of molecular medicine in the de Pater / Heidt research groups
Qualifications and skills
The preferred candidate holds a master degree (MSc) in the life sciences. Experience in cellculture and molecular biology is an advantage and experience in large dataset analysis is preferred. Applicants with a background in immunology are also encouraged to apply.
Before you apply please check our conditions for employment.
Terms of employment
- You will receive a temporary position for 4 years.
- The gross monthly salary according to CAO UMC (scale OIO).
- Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
- An International Office which aids you in preparing for you arrival and stay.
- Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
- Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.
More information
For more information, please contact Emma de Pater (groupleader) e.depater@erasmusmc.nl for more information about the position. For other information contact Tessa Mannee (secretary) t.mannee@erasmusmc.nl.
No agencies please.
Application proces
Application proces
Step 1 - Apply
Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.
Step 2 - Selection
Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.
Step 3 - Job interview
You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.
Step 4 - Offer and terms of employment
It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.
Step 5 - Getting started
Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!
