OIO lab Gao - Cerebellar nuclei: from single-neuron projections to functions

Job description

The cerebellar nuclei (CN) are the sole output channels of the cerebellar cortex, yet their internal organization and the functional diversity of single CN neurons remain poorly understood. This PhD project aims to unravel the relationship between the axonal projection patterns of individual CN neurons and their roles in motor and non-motor behavior. Using state-of-the-art viral tracing, high-resolution imaging, and in vivo electrophysiology combined with optogenetics, you will map projection motifs at the single-neuron level and test how distinct CN output pathways contribute to behavior in mice.

As a PhD candidate, you will: 

• Map single-neuron projection patterns using modern neuroanatomical tracing techniques, fMOST, trans-synaptic tracing. 
• Record neuronal activity during behavior (e.g., neuropixels).
• Analyze neural data to link circuit structure to function.
• Design and perform behavioral experiments in mice.
• Contribute to publications in international journals and collaborate within a multidisciplinary neuroscience environment.

Work environment

You will work in the Department of Neuroscience within a well-equipped lab offering viral vector core facilities, two-photon and light-sheet microscopy, electrophysiology rigs, and behavioral setups. The project is embedded in a collaborative network with the Dutch Brain Institute (Amsterdam) and international partners. 

This project is embedded in the host lab of Dr. Zhenyu Gao, under the joint supervision of Dr. Xiaolu Wang. English is widely spoken at the workplace. Please see our lab description and recent work via the link below.

https://neuro.nl/research/gao

Qualifications and skills

• Master’s degree in Neuroscience, Biophysics, (Neuro)Engineering, or a related field.
• Prior experience with rodent stereotaxic surgery, viral tracing, or in vivo recording is highly desirable.
• Strong affinity with quantitative data analysis; programming skills (Python, MATLAB, or R) are a plus.
• Excellent communication skills in English (Dutch not required, but willingness to integrate is appreciated).
• Ability to work independently and as part of a collaborative team. 

Before you apply please check our conditions for employment.

Terms of employment

• You will receive a temporary position for 4 years.
• The gross monthly salary amounts a minimum of €3.217 and a maximum of €4.077 (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as an incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work. 

More information

Interested candidates please add an up-to-date CV, a motivation letter, and contact details of 2 references (included in the motivation letter) with your application. You will be invited for an interview if your CV meets the requirements of this project. 

No agencies please.