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PhD candidate on autism models in zebrafish

  • 42.15.18.TBW
  • 36 hours per week
  • Celbiologie

Job description

Autism affects 1% of the population but its molecular causes are poorly understood. Zebrafish models of autism, generated by CRISPR-Cas9-induced gene mutations or chemicals, are useful to identify disrupted biological pathways and brain developmental processes and associated zebrafish behavioral phenotypes. Importantly, zebrafish embryogenesis is highly accessible to complementation by genetic means or chemical compounds.

In the project the PhD student will generate zebrafish autism models with the aim to complement the accompanying brain and behavioral phenotypes. We will employ in CRISPR-Cas-9 induced mutagenesis, RNA-seq, brain microscopy and behavioral testing in zebrafish.

Your responsibilities will include co-designing and performing experiments, data analysis, documenting and reporting results in lab- and departmental meetings and at (inter-)national conferences.

Work environment

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The Transcriptional regulators of cognition group is part of the Department of Cell Biology, which houses innovative technologies and top-level facilities to support its research programs. The main focus of the department is on transcription regulation and genome organization in (neuro-)developmental and blood cell forming systems. The department is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within the Erasmus MC. The main language of the research community is English. During the PhD training, our students follow specialized lab courses organized by the Graduate School at Erasmus MC.

Qualifications and skills

We are looking for a talented, highly motivated candidate that holds an MSc degree in Biomedical Science, Neuroscience or a related field and has experience with zebrafish. Experience with CRISPR-cas9, a brain-related topic and/or zebrafish behavioural testing is a plus. You are an effective communicator, combining independent thinking with a collaborative attitude. Being able to present a certificate of good conduct is a condition for the appointment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.279 ,- in the 1st year and increases to € 2.919,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application

For more information about this position, please contact Dr. Raymond Poot, group leader and Associate Professor, phone number: +31 (0)10 704 33 52 or e-mail: Visit our lab website.
For queries regarding your application, please contact Jerry Chandansingh, recruiter, phone number: +31 (0)10 704 49 83.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.