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PhD student on Identification of Unique Fetal Thyroid Hormone Metabolites in Maternal Serum to Guide Therapy

  • 52.12.18.TD
  • 36 hours per week
  • Inwendige geneeskunde

Job description

Thyroid hormone (TH) is essential for normal development of virtually all tissues, especially the brain. Untreated maternal hypothyroidism during pregnancy is associated with an increased risk of adverse pregnancy and child outcomes. Even mild maternal thyroid dysfunction adversely affects child cognitive development resulting in lower IQ scores and an increased risk of autism, ADHD and schizophrenia. As a consequence, current guidelines advocate treatment with levothyroxine (LT4) in over 5% of pregnant women. However, current LT4 treatment is merely guided by maternal thyroid parameters, because reliable non-invasive markers of fetal TH status to monitor LT4 therapy are lacking. The identification of accurate markers of fetal thyroid status is therefore of major importance, as this will allow tailored treatment of pregnant women to optimize development of their unborn children.

The main goal of the project is to develop a Mass Spetometry based method to detect unique fetal metabolites in maternal serum. Development and clinical validation of novel methods to analyze thyroid diseases, particularly during pregnancy, will therefore be the main focus.

Work environment

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The Academic Center for Thyroid Disease of Erasmus MC is an internationally well-know expertise center for thyroid diseases. The main goal is to continuously improve care for thyroid patients via a better understanding of diseases. The project is a collaborative effort between the Thyroid Laboratory of the Department of Internal Medicine (internationally recognized for its expertise in studies on regulation of thyroid hormone action) and the Department of Clinical Chemistry (one the largest diagnostic laboratories in the Netherlands with a strong focus on innovation and method development).

Qualifications and skills

You have completed academic training in Analytical Chemistry, Medical Biology or Pharmacy and have experience with mass spectrometry analysis (GC-MS and / or LC-MS) and statistical processing of data. You are analytical, creative, innovative, team-oriented and fluent in English (in word and writing).

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.357 ,- in the 1st year and increases to € 3.020,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application

For more information about this position, please contact Prof.dr. R.P. Peeters, Professor of Internal Medicine at the Academic Center for Thyroid Disease, Erasmus MC, phone number: +31 (0)10 704 49 86 or Dr. M. Meima, tel +31 (0)10 704 49 86 or Prof.dr. Y.B. de Rijke, Department of Clinical Chemistry, phone number +31 (0)10 703 35 43. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, phone number: +31 (0)10 704 49 83.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.