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PhD student - To understand the effect of disrupted thyroid hormone signaling in the brain

  • 17.02.19.TD
  • 36 hours per week
  • Inwendige geneeskunde

Job description

Thyroid hormone is crucial for development and metabolism of virtually all tissues, particularly the brain. Defects in thyroid hormone signaling comprise impaired neurological development. Defective transport of thyroid hormone into neural cells (e.g. MCT8 deficiency), resulting in disrupted thyroid hormone signaling in the brain, likely underlies the mechanism of disease of the neurocognitive phenotype.

Our aim is to understand the mechanisms underlying the neurocognitive phenotype of disorders due to disrupted thyroid hormone signaling. We employ induced Pluripotent Stem Cells (iPSCs) technology as an advanced unique human model, which allows studying living neural cells from patients.

The main goal of the project is to investigate neural lineages from patient-derived iPSCs. These results will provide insight in the mechanisms underlying the neurocognitive phenotype of patients with disrupted thyroid hormone signaling. We are conducting this research in the department of Endocrinology (Thyroid laboratory) in collaboration with the department of Neurobiological Psychiatry.

Work environment

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The Academic Center for Thyroid Disease of Erasmus MC is an internationally well-known expertise center for thyroid diseases. The main goal is to continuously improve care for thyroid patients via a better understanding of diseases. The project is a collaborative effort between the Thyroid Laboratory of the Dept of Internal Medicine (expertise in thyroid hormone signaling) and the Neurobiological Psychiatry (high-quality research in the application of human iPSCs to model rare neurodevelopmental disorders).

Qualifications and skills

We are looking for a candidate with a master degree in Molecular Medicine, Neuroscience, Cell Biology or related field. The candidate is expected to have a solid background in Cell Biology, in cell culture work (experience with Induced Pluripotent Stem cells and neural differentiation protocols is desirable), immunolabeling and confocal imaging. We are looking for a pro-active, analytical and collaborative candidate who has an open attitude and communicates easily in English speech and scientific writing.

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.357,- in the 1st year and increases to € 3.020,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application

For more information about this position, please contact Dr. W. Edward Visser or Dr. Nilhan Gunhanlar, phone number: +31 (0)10 704 49 86. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, phone number: +31 (0)10 703 18 92.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.