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PhD student - In vivo imaging of orthotopic tumor models, imaging and interaction with hyperthermia

  • 19.12.19.TBW
  • 36 hours per week
  • Moleculaire Genetica

Job description

The Department of Molecular Genetics is looking for a highly motivated PhD student with a strong background in biomedical technology and/or small animal in vivo imaging. The department studies the molecular mechanisms of multicomponent biological pathways within the DNA damage response. INTO-PROT is a 4-year collaborative research project aiming at further improving proton therapy of cancer funded by a Dutch Cancer Society Consortium grant. The project aims to define the therapeutic efficacy of proton versus photon irradiation and identify any proton-combination treatments for head and neck cancer that are superior to photon irradiation.

Within the INTO-PROT project you will make use of X-ray CT and fluorescence based molecular tomography yielding complementary information on both anatomy and biological activity of the tumor. Quantitative analysis of these data will be set up to take full advantage of the acquired information and to study spatiotemporal changes with high sensitivity, accuracy, and reproducibility. To this end we will develop novel image analysis techniques for automatic image alignment, detection and segmentation of relevant image structures, and quantitative measurements of the spatial and temporal properties of these structures.

Work environment

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The candidate will be positioned at the Department of Molecular Genetics and will work in with research teams that address various aspects of the DNA damage response at the molecular, cellular and physiological level. The department of Molecular Genetics is a vibrant and international group of more than 80 researchers working on various aspects of DNA damage, DNA repair and other DNA damage related responses. More information about the research activities of the department can be found here.

Qualifications and skills

The candidate should have a Master’s degree or equivalent in M.Sc. degree in Biomedical Sciences, Molecular Life Sciences, Biochemistry. Basic knowledge of programming, expertise in radiation physics; radiation transport; Monte Carlo and medical imaging techniques and experience in performing experiments at accelerator facilities are an asset. The candidate will be involved in several projects in close collaboration with biochemists and molecular biologists. Furthermore, a strong command of (scientific) English in speech and writing is essential.

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.357 ,- in the 1st year and increases to € 3.020,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application

For more information about this position, please contact: For queries regarding your application, please contact Jerry Chandansingh, Recruiter, phone number: +31 (0)6 500 310 06.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.