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PhD student on Obesity

  • Research & Education
  • 36 hours
  • Internal Medicine

  • Closing date 27-02-2020
  • 03.16.20.TD

Job description

Obesity is a global health care problem and forms a major risk factor for metabolic comorbidities such as diabetes, cardiovascular disease, and cancer. While the obesogenic environment has contributed to increased obesity rates, genetic factors modulate the susceptibility for obesity. Our research within the Obesity Center CGG (Centrum Gezond Gewicht) shows that obese patients frequently harbor genetic mutations or variants as an underlying cause of their obesity, particularly in children with an early onset of severe obesity.

The Laboratory of Metabolism and Reproduction in the Department of Internal Medicine has a vacant PhD position for a project aimed at understanding the functional consequences of these mutations. The PhD candidate will apply various signaling assays to study several receptor signaling pathways. Obtained results will be analyzed for genotype-phenotype correlation. This research will contribute to personalized treatment of obesity as it may aid in the selection of patients for specific therapeutic treatments. 

Work environment

The Department of Internal Medicine is a large department with several research groups. The research group “Metabolism and Reproduction” focuses on various aspects of obesity, including functional genetics of obesity, sex differences in obesity and the interaction between gonadal function and metabolism. We approach our research questions using physiological and molecular techniques in cell systems, animal models and humans. An important principle that guides our efforts is the possibility to apply our findings in the clinic and, vice versa, paying attention to questions that arise in the clinic when treating patients. You will be a member of a team that consists of other PhD students, basic scientists and clinical scientists. You will interact and collaborate closely with researchers of the CGG team, supervised by Prof. E.F.C. van Rossum and Dr. E.L.T. van den Akker.

Qualifications and skills

You are a highly motivated candidate with an MSc in Biology, Biomedical Sciences or a related discipline with an interest in Endocrinology and Obesity. Experience with molecular biology, receptor signaling and metabolic physiology is strongly preferred. You are capable to work independently and in a multidisciplinary environment. You have excellent communication and writing skills.

Before you apply please check our conditions for employment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.422,- in the 1st year and increases to € 3.103,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application

For more information about this position, please contact Dr. ir. Jenny Visser, Associate Professor, Head Lab Metabolism and Reproduction, phone number: +31(0)10 703 05 33 or e-mail: For queries regarding your application, please contact Jerry Chandansingh, Recruiter, phone number: +31 (0)6 500 310 06. Please respond by using the apply button.

No agencies please.

Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Our roots lie in Rotterdam, a city and port of international standing. We are the most innovative university medical center in the Netherlands and one of the world’s leading centers of scientific research. With passion and dedication we are committed to achieve a healthy population and pursuing excellence in healthcare through research and teaching. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

Learn more about our ambitions