The candidate will work on testing the hypothesis that cartilage of patients with SMAD3 mutations is more sensitive to inflammation compared to the normal population, and therefore more prone to degeneration leading to osteoarthritis. Aneurysms-osteoarthritis syndrome (AOS) is a rare genetic condition caused by mutation(s) in the SMAD3 gene and Erasmus MC is the reference national hospital to assist and treat these patients. The SMAD3 protein is one of the main intracellular signalling effectors of transforming growth factor-β (TGF-β) family members, which have a pivotal role in regulating connective tissue development and maintenance, cartilage included.
With this project the candidate will be involved in the generation of a human, iPSC-based, osteoarthritis model and test how inflammatory conditions of the joint of these patients influence cartilage maintenance/degeneration. The candidate will be involved in culturing and analyzing cells of human origin (including iPSC), in 3D differentiation assays and in samples analysis involving transcriptomic, proteomic analysis and, possibly, metabolomics.
The research laboratory of the Department of Orthopaedics performs basic/translational research in a highly multidisciplinary environment, with strong on going collaborations especially with the Erasmus MC iPSC Core Facility, and the departments of Clinical Genetics, Internal medicine and Molecular Genetics.
Qualifications and skills
The candidate should hold a PhD on a discipline relevant to the tasks required (e.g. Biology, Stem Cell, Regenerative Medicine, Biotechnology). Extensive experience (≥3 years) in classical molecular and cellular biology assays as well as in cell culturing is necessary. Candidates with experience in handling (human) iPSCs will be considered first. We are looking for a highly motivated candidate willing to challenge himself in new multidisciplinary projects, able to work independently and with proven skills in dissemination of scientific results.
Before you apply please check our conditions for employment.
Terms of employment
- The appointment is for a period of 18 months with the possibility to further extend the contract in case funding and the results collected will allow so.
- Flexible working hours can be considered on individual cases.
- The gross monthly salary amounts to a maximum of € 4.481,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours.
- Erasmus MC offers a standard end-of year bonus of 8.3%, an individual commuting allowance and a range of possibilities for courses for further development of academic skills.
- The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).
Information and application
For more information about this position, please contact Roberto Narcisi, Assistant Professor at the Department of Orthopaedics, e-mail: firstname.lastname@example.org. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, by phone number: +31 (0)6 500 310 06.
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website
No agencies please.