Peptide receptor radionuclide scintigraphy and peptide receptor radionuclide therapy are methods successfully applied in the clinic for imaging and treatment of neuroendocrine tumors and other cancers. For this, radiolabeled peptide analogs are applied that target molecules overexpressed on cancer cells. Following the success of these strategies in neuroendocrine tumors, peptide analogs have been designed for imaging and treatment of other tumor types, such as prostate cancer and breast cancer. In the past decades gastrin releasing peptide (GRP) analogs have been developed that target the gastrin releasing peptide receptor (GRPR), a g-protein coupled receptor that is overexpressed on prostate cancer and breast cancer cells. These GRP analogs can be radiolabeled with different radionuclides and have successfully been used in preclinical and clinical pilot studies. Despite these positive results there is still room for improvement of GRPR-targeted radiolabeled peptide analogs and their application, amongst other with regards to uptake in healthy organs, patient selection and possible combination treatments.
You will work on improving/optimizing the application of radiolabeled GRPR analogs. The project is highly multi-disciplinary involving radiochemistry, in vitro cell and tissue assays, in vivo experimentation in models of cancer using SPECT, PET and examination of tumor tissue.
The Department of Radiology & Nuclear Medicine is the largest Department of Radiology in the Netherlands and one of the largest in Europe. Our Department is dedicated to high quality patient care, education, and research. Concerning research, the Department is known for its forefront research and its state-of-the-art facilities.
Qualifications and skills
You are a highly motivated candidate with a BSc degree.
- You have outstanding theoretical and experimental research skills, are well organized and result-driven with a strong team spirit.
- You have strong English skills.
- You have received excellent scientific training in the field of (molecular) biology, oncology or a related field.
- Experience with animal studies, radiolabeling and radionuclide imaging will be considered as an advantage.
Before you apply please check our conditions for employment.
Terms of employment
The appointment is available from May 1st, 2020. You will receive a temporary position for 2 years. The gross monthly salary is € 3.184,00. The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).
Information and application
For more information about this position, please contact Dr. Simone Dalm, project leader, phone number: +31 (0)10 704 1033 . For queries regarding your application, please contact Jerry Chandansingh, Recruiter, by phone number: +31 (0)6 500 310 06.
Your application must include the following documents:
- Cover letter explaining your motivation and suitability for the position.
- Contact information of 2 senior scientists or principle investigators as references, willing to provide recommendation letters or enquiry.
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
No agencies please.