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PhD candidate on bridging gene regulation and cohesin loop extrusion

  • Closing date 24-10-2022
  • 33.08.22.TDA
  • 36 hours
  • Research university
  • Research & Education

Questions? Contact our recruiter

  • Closing date 24-10-2022
  • 33.08.22.TDA

Job description

The regulation of genome activity is highly dependent on and controlled by the three-dimensional organization of the genome. On major player controlling these structures is the cohesin complex. Cohesin actively extrudes chromatin loops while other factors determine the length and position of the chromatin loops.

In this project we will study the regulation of loop extrusion and the role of active transcription therein. Further, we will look into the implications of these mechanisms for pathologies linked to mutations in cohesin and cohesin regulators observed in human developmental syndromes, for example Cornelia de Lange Syndrome (CdLS).

We will employ a wide range of techniques from CRISPR genome editing, biochemistry, ChIP-sequencing/Cut&Run, chromatin conformation capturing as well as super-resolution imaging.

Work environment

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting ground-breaking work, we aim to push boundaries through leading the way in research, education and healthcare. We work with the latest equipment and techniques in a state-of-the-art environment.

Core facilities like the Erasmus Center of Genomics or the Optical Imaging Center will be important collaborators for the project. The department of Cell Biology is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within the Erasmus MC. You will join the Erasmus MC Graduate school and follow the Biomedical Sciences PhD track. The main language in the department is English.

Qualifications and skills

  • You hold a MSc or equivalent degree in Molecular biology, Nanobiology, Bioinformatics or a related field, and have a strong interest in a project bridging bench work and data analysis.
  • Prior experience with genomics techniques and genomics data analysis or Python/R studio skills are an advantage.
  • You have excellent communication skills in both written and spoken English.

Before you apply please check our conditions for employment.

Terms of employment

  • You will receive a temporary position for 4 years.
  • The gross monthly salary is € 2.631,- in the 1st year and increases to € 3.336,- in the 4th year (scale OIO).
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
  • Pension insurance with ABP, we take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as an incompany physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.

More information

For more information about this position, please contact dr. K.S. Wendt,

You can apply by using the application button on our website.

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Jerry Chandansingh

Jerry Chandansingh
Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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