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PhD student on modelling human ovary development in vitro


 


  • Closing date 29-09-2022
  • 35.08.22.TBW
  • 36 hours
  • Research university
  • Research & Education
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Questions? Contact our recruiter

  • Closing date 29-09-2022
  • 35.08.22.TBW

Job description

In a large collaborative project financed by NWO entitled: HipGametes: In vitro generation of human induced pluripotent stem cell-derived gametes to model human embryogenesis, a PhD position is available in the Baarends group at the department of Developmental Biology.

The project aims to develop human female in vitro meiosis protocols to eventually generate mature egg-like cells that could be used to generate nonviable human embryo models. The project will involve optimization of in vitro differentiation protocols using state of the art methods, starting from induced pluripotent stem cells. Scientific questions that will be addressed involve identification of the key regulators of human granulosa cell formation, and the prerequisites for human ovary organoid formation capable of supporting oogenesis from in vitro differentiated primordial germ cell-like cells.

To this end, the candidate will employ a multidisciplinary approach, develop cell differentiation and organoid culture protocols, use various molecular biology assays (incl. CRISPR-Cas9 technology), next generation sequencing, and (super resolution) microscopy.

Work environment

The Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have a high level of expertise, and work hard to improve and renew the healthcare of today and the public health of tomorrow. We have access to the latest equipment and techniques in a state-of-the-art environment.

The candidate will be appointed at the Department of Developmental Biology in the research team of Dr. WM Baarends. The group uses a multidisciplinary approach to advance understanding of gametogenesis in the context of sex-specific gonad development with a special focus on meiosis.

The Department of Developmental Biology performs basic research and is involved in several teaching and training programs. We aim to unravel the epigenetic mechanisms regulating cell fate decisions in the cycle of life, and to translate this knowledge to understand deregulations that may occur in X-linked diseases, cancer, infertility, and aging. The candidate will be offered excellent training and supervision platform through a dedicated teaching program of our Graduate school.

Qualifications and skills

  • We seek an ambitious candidate that holds an MSc degree in in Biomedical Science, Molecular/ Cellular Biology, Nanobiology, or related field with a keen interest in molecular regulation of developmental biology processes, in particular gametogenesis.
  • Experience in cell culture and molecular biology methods, as well as knowledge of cell-cell signalling and molecular (epi)genetics are an advantage

Before you apply please check our conditions for employment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.631 in the 1st year and increases to € 3.336,- in the 4th year (scale OIO). The terms of employment are according to the Collective Labour Agreement for Dutch University Medical Centers (CAO UMC).

More information

For more information about this position, please contact Dr. W.M. Baarends, project leader, e-mail: w.baarends@erasmusmc.nl.

Your application must include the following documents:

  • Cover letter explaining your motivation and suitability for the position.
  • CV/resume including your final marks, research projects and other relevant experience. Please include contact information of 2 senior scientists or principle investigators as references, willing to provide recommendation letters or enquiry in your CV. Do not upload this as a 3rd document!

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Jerry Chandansingh
Recruiter

Jerry Chandansingh
Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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