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Postdoc with experience in immunology and/or infectious diseases

Are you an enthusiastic scientist with a PhD degree in immunology or infectious disease? Would you like to investigate a new type of antibiotics for non-tuberculous mycobacteria? Then this is the post-doc position for you!
  • Closing date 17-10-2022
  • 38.04.22.TS
  • 36 hours
  • Research university
  • Research & Education
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Questions? Contact our recruiter

  • Closing date 17-10-2022
  • 38.04.22.TS

Job description

We offer a 2-year post-doc position to test a new generation of antibiotics, so-called non-digestible oligosaccharides (NDOs) as a treatment for respiratory tract infections with Non-Tuberculous Mycobacteria (NTM) in people with cystic fibrosis (CF). This project is funded by Dutch CF Foundation and St TAAI and unites the expertise of 5 academic research groups (Pharmacology University Utrecht; Microbiology Radboud UMC, Radiology-Nuclear Medicine; Pediatric Infectious Disease and Pediatric Pulmonology Erasmus MC).

Lung infections with Non-Tuberculous Mycobacteria (NTM) are an increasing problem for both adults and children with CF. Antibiotic treatment of NTM is complex and lengthy, with high risk of serious side effects. In addition, the success rate is low. Thus, there is a need for more effective and less toxic antibiotics. We have found that a specific group of sugars, so-called non-digestible oligosaccharides (NDOs) can inhibit bacteria in growth or even kill them.

You will test the effectivity of NDOs as treatment of NTM infections both ex-vivo, using lung organoids or primary macrophages derived from people with or without CF; as well as in-vivo, using mouse models for NTM pulmonary infection (including luciferase-based in vivo imaging techniques) and assess optimal treatment regimens.  You will perform assays to analyse the host (immune) response but also perform assays that address the bacteria.

You will perform this research independently, but in close collaboration with other experienced lab members as well as interact with the other groups involved in the project.

Work environment

A challenging position within the largest University Medical Center (UMC) in the Netherlands with high ambitions in the areas of care, education and research.

The successful applicant will be based at the Laboratory of Pediatrics, Erasmus University Medical Center (Erasmus MC), and work in the team of Dr. Wendy Unger (Laboratory of Pediatrics) and Dr. Hettie Janssens (Pediatric Pulmonology/head CF Center Sophia Children’s hospital).

As a research laboratory, the Pediatrics Laboratory is directly affiliated with the Sophia Children's Hospital. Our research focuses on studying disease in the developing child with a special focus on infection and the response of the developing immune system. There is a strong interaction with various clinical departments in the hospital, such as the departments of Pediatric Pulmonology, Pediatric Infectious Diseases/Immunology and Medical Microbiology, which allows discoveries from research to be quickly translated into practice but also vice versa to generate clinically relevant questions for new research goals.

Qualifications and skills

  • Ph.D. degree in Immunology, Infectious Disease or other biomedical field.
  • Strong background in immunology and/or infectious diseases are required.
  • Experience with primary cell cultures, preclinical (animal) models, assays to analyse the host response but also bacterial assays are desired.
  • You are a team player, enthusiastic and positive attitude, and open communication style. 

Techniques are partially established but some also need to be newly developed. This project includes handling with animals and patient materials.

Before you apply please check our conditions for employment.

Terms of employment

  • A temporary contract for the duration of 2 years
  • The gross monthly salary amounts a maximum of € 4.800,- (scale 10), depending on your level of education and relevant experience, based on a full-time working week of 36 hours.
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
  • Pension insurance with ABP, we take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as an incompany physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.

More information

For more information about this position, please contact Wendy Unger, project lead and head Infection&Immunity research group, e-mail: w.unger@erasmusmc.nl, or  Hettie Janssens, pediatric pulmonologist and head CF Center Sophia Children’s Hospital, e-mail: h.janssens@erasmusmc.nl

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Alexandra Goud
Recruiter

Alexandra Goud
Erasmus MC

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Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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