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Research technician position at the department of Clinical Genetics

You will be involved in establishing and maintaining advanced induced pluripotent stem cell (iPSC)-derived neural cultures (neurons, brain organoids).
  • Closing date 04-10-2022
  • 38.09.22.TS
  • 36 hours
  • University of Applied Sciences
  • Research & Education
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Questions? Contact our recruiter

  • Closing date 04-10-2022
  • 38.09.22.TS

Job description

Neurodevelopmental disorders are severe conditions impacting the life of patients and families. In the Barakat lab at the department of Clinical Genetics we investigate the role of gene regulation in these disorders, providing new insights for diagnostics, understanding of the disease mechanisms and future therapy development.

Our new project, funded by a ZonMw PSIDER grant, is focused on understanding how certain variants in a chromatin modifier gene are contributing to brain development and neural function and what are the cellular events behind the pathology of the disorder caused by these variants.  

As a research assistant you will be involved in establishing and maintaining advanced induced pluripotent stem cell (iPSC)-derived neural cultures (neurons, brain organoids); study their functionality (electrophysiology) and gene expression profiles. You will work with iPSC, human embryonic stem cells and modify them with genetic engineering tools (CRISPR/Cas9, base editing). For the downstream analysis we will use (single-cell)RNA-seq, methylation profiling, immunofluorescent imaging, multi-electrode arrays etc. You will work with a postdoc and a PhD student on the main project and be involved in overall research activities of the group. For graduated MSC students, using this temporary position as a bridge to a follow-up PhD project could be an option.

Work environment

(https://www.erasmusmc.nl/en/research/groups/barakat-lab-non-coding-genome-in-clinical-genetics) . We offer a welcoming and collaborative environment, where we work together for a common goal and where your contributions are recognised. The department of Clinical Genetics at the Erasmus MC is a leading institute for excellent genetic research on several forms of hereditary diseases, with a special focus on understanding basic molecular disease mechanism enabling future treatment of genetic diseases. A leading focus in this is on neurogenetic disorders including epilepsy (with the research groups of Mancini, Bonifati, Willemsen, Barakat, and Van Ham). We combine the use of patient materials, in vivo models (zebrafish, mouse) with state-of-the-art molecular and genetic approaches (next-generation-sequencing, epigenome-profiling, biomics, metabolomics).

An overview of some of our department’s research activities can be found at https://youtu.be/ifoF6y4rqIs . Our laboratory is equipped with all required facilities and equipment and can also make use of Erasmus MC Core-facilities (e.g. FACS, Cancer-treatment screening facility (CTSF), iPSC-, animal facility). Our department is embedded within the Pediatric Brain Centre (Sophia Children’s Hospital), is an NFU registered expertise center for Brain malformations, within the expertise center ENCORE, which is partner of ERN ITHACA, the European Reference network on rare congenital malformations (http://www.ernithaca.org/#). Our department has further strong collaborative bonds to the Erasmus MC departments of Cell Biology, Biochemistry, and Neuroscience, including various shared weekly scientific meetings.  

Qualifications and skills

  • You are highly motivated candidate with HBO/master’s degree in Biology, Biomedical sciences or related disciplines.
  • You have a can-do attitude and are organised in your experimental work.
  • You are experienced with cell culture and iPSC-work (preferably differentiation to neural cultures, brain organoids).
  • You should be fluent in English (the working language in the lab).

Before you apply please check our conditions for employment.

Terms of employment

  • Temporary position for 18 months, starting November 1st, 2022
  • The gross monthly salary amounts a maximum of € 3.422,- (scale 7), depending on your level of education and relevant experience, based on a full-time working week of 36 hours.
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
  • Pension insurance with ABP, we take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as an incompany physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.

More information

For more information about this position, please mail Dr. Stefan Barakat, Principal Investigator, t.barakat@erasmusmc.nl or Dr. Kristina Lanko, postdoctoral researcher, k.lanko@erasmusmc.nl 

In case of other requirements to apply:
Your application should include: motivation letter, Curriculum Vitae, list of courses and obtained grades during BSc and/or MSc program, a publication list, and a minimum of two reference letters.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
 

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Alexandra Goud
Recruiter

Alexandra Goud
Erasmus MC

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Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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