Problem: Patients with congenital heart disease (CHD) have an increased risk of developing heart failure. Currently there is no treatment for this type of heart failure, which is partly due to a lack of proper models representing heart tissue from patients with CHD. Induced pluripotent stem cell (iPSC)-derived cardiomyocytes may offer new opportunities; however, 2D-cultures have limitations for studies on heart failure. Living Tissue Slices, 3D-cultures developed from residual heart tissue isolated at operation, may offer additional opportunities to study mechanisms of heart failure in CHD and test therapeutic strategies.
In this project, funded by the Dutch Heart Foundation, the PhD student will use a combination of iPSC-derived cardiomyocytes and Living Tissue Slices to study mechanisms of heart failure in CHD. The student will develop patient-derived and genetically engineered iPS-derived cardiomyocytes and Living Tissue Slice models, and study their molecular and electrical behaviour and physiology using various approaches. The PhD student will work in the laboratory of Cell Biology and the Translational Cardiothoracic Surgery Research Lab. The research is embedded in the Erasmus MC Cardiovascular Institute. This Institute fosters interdepartmental collaboration within healthcare, research, and education to create the best treatment and outcomes for cardiovascular patients.
The PhD student will be supervised by Beatrijs Bartelds (Pediatric Cardiology), Niels Galjart (Cell Biology) and Dr. Yannick Taverne (Translational Cardiac Surgery).
A healthy population and excellence in healthcare through research and education - this is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way in research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.
Qualifications and skills
- MSc degree in biomedical sciences, medicine or a related discipline.
- Affinity with stem cells / cell cultures
- Working well in a team and independently
- Relevant research experience
- Excellent writing and presenting skills
- Proficiency in English is required
Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.
Before you apply please check our conditions for employment.
For more information about this position, please contact Beatrijs Bartelds, Pediatric Cardiology, email@example.com
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
No agencies please.