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PhD Health science or Biology

An opportunity to study mechanisms of heart failure in patients with congenital heart disease and to test therapeutic strategies.
  • Closing date 16-12-2022
  • 46.13.22.TS
  • 36 hours
  • Research university
  • Research & Education
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Questions? Contact our recruiter

  • Closing date 16-12-2022
  • 46.13.22.TS

Job description

Problem: Patients with congenital heart disease (CHD) have an increased risk of developing heart failure. Currently there is no treatment for this type of heart failure, which is partly due to a lack of proper models representing heart tissue from patients with CHD. Induced pluripotent stem cell (iPSC)-derived cardiomyocytes may offer new opportunities; however, 2D-cultures have limitations for studies on heart failure. Living Tissue Slices, 3D-cultures developed from residual heart tissue isolated at operation, may offer additional opportunities to study mechanisms of heart failure in CHD and test therapeutic strategies.

In this project, funded by the Dutch Heart Foundation, the PhD student will use a combination of iPSC-derived cardiomyocytes and Living Tissue Slices to study mechanisms of heart failure in CHD. The student will develop patient-derived and genetically engineered iPS-derived cardiomyocytes and Living Tissue Slice models, and study their molecular and electrical behaviour and physiology using various approaches. The PhD student will work in the laboratory of Cell Biology and the Translational Cardiothoracic Surgery Research Lab. The research is embedded in the Erasmus MC Cardiovascular Institute. This Institute fosters interdepartmental collaboration within healthcare, research, and education to create the best treatment and outcomes for cardiovascular patients.

The PhD student will be supervised by Beatrijs Bartelds (Pediatric Cardiology), Niels Galjart (Cell Biology) and Dr. Yannick Taverne (Translational Cardiac Surgery). 

Work environment

A healthy population and excellence in healthcare through research and education - this is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way in research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

Qualifications and skills

  • MSc degree in biomedical sciences, medicine or a related discipline.
  • Affinity with stem cells / cell cultures
  • Working well in a team and independently
  • Relevant research experience 
  • Excellent writing and presenting skills
  • Proficiency in English is required 

Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Before you apply please check our conditions for employment.

Terms of employment

  • A 1-year contract will be offered at first, you will work towards a PhD thesis. A 3-year extension will be offered on proven ability. 
  • The gross monthly salary is € 3.336,- (scale OIO), depending on your level of education and relevant experience and based on a full-time working week of 36 hours.
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
  • Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

More information

For more information about this position, please contact Beatrijs Bartelds, Pediatric Cardiology, b.bartelds@erasmusmc.nl 

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Job interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms of employment

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Alexandra Goud
Recruiter

Alexandra Goud
Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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