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Cardiologie Erasmus MC

PhD student in DNA repair

Novel genome maintenance mechanisms that control ERCC1-XPF activity.
  • Closing date 30-01-2023
  • 02.07.23.TBW
  • 36 hours
  • Research university
  • Research & Education

Questions? Contact our recruiter

  • Closing date 30-01-2023
  • 02.07.23.TBW

Job description

ERCC1-XPF is an endonuclease complex that has essential functions in multiple DNA repair pathways and is therefore one of the major cellular defence factors protecting against mutation, cancer and aging. The medical importance of ERCC1-XPF is illustrated by the severe cancer-prone and progeroid diseases, such as xeroderma pigmentosum, Cockayne syndrome and Fanconi anemia, that are caused by its deficiency. ERCC1-XPF has been investigated in much detail in relation to its function in nucleotide excision repair, which is a versatile DNA repair pathway that removes DNA damage caused by solar UV light and certain cancer chemotherapeutics. However, ERCC1-XPF function in other DNA repair pathways, including interstrand crosslink repair, is less well investigated.

In this project, the PhD candidate will study cellular mechanisms that control ERCC1-XPF activity in DNA repair and characterize novel DNA repair mechanisms in which ERCC1-XPF is involved. To this end, a multidisciplinary approach will be employed, with molecular, genetics and cell biological techniques ranging from DNA repair assays, genetic screening, CRISPR-Cas9 gene editing to confocal imaging and quantitative proteomics, using both human cells and C. elegans as model systems.

Work environment

The Department of Molecular Genetics has a long-standing world-wide established reputation in dissecting the DNA damage response at the molecular, cellular and physiological level. The department consists of a vibrant and international group of more than 80 researchers working on various aspects of DNA damage, DNA repair and related pathways. This project will be carried out in the group of Dr. Hannes Lans , which investigates molecular mechanisms of the DNA damage response in relation to DNA repair disease and cancer therapy. For this, we use molecular genetics and cell biological techniques in both mammalian cells and C. elegans and strongly focus on state-of-the-art live cell imaging. Our group collaborates intensively with the other groups within our department and together we act internationally at the forefront of the DNA repair field. We offer a dynamic, challenging, and cooperative research environment and an excellent training and supervision platform through a dedicated PhD teaching program of our Erasmus MC Graduate School.

The Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare to improve and renew the healthcare of today and the public health of tomorrow. To stimulate research, the Erasmus MC provides access to the latest equipment and techniques in a state-of-the-art environment.

Qualifications and skills

  • We are seeking a highly motivated and talented candidate that holds a MSc degree in Biomedical Sciences, Molecular/Cellular Biology, Nanobiology, Biochemistry or a related field.
  • Experience with standard molecular biology techniques and live cell imaging will be a strong advantage.
  • As you will work in a dynamic international research environment, we need a team-player who is able to combine independent thinking with a collaborative attitude.
  • A strong command of (scientific) English in speech and writing is essential (EUR requirements minimum IELTS overall score of 7.0 [comparable to TOEFL PBT: 600; TOEFL CBT: 250; TOEFL IBT: 95]).

Before you apply please check our conditions for employment.

Terms of employment

  • You will receive a temporary position for 4 years.
  • The gross monthly salary is € 2.789,- in the 1st year and increases gradually to € 3.536,- in the 4th year (scale OIO).
  • A 4% Collective Labour Agreement payraise starting November 2023.
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and a induvidual travel expense package.
  • Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a sports club where you can work on your fitness after work.
  • An Internanational Office which aids you in preparing for your arrival and stay. 

More information

For more information about this position, please contact Dr. Hannes Lans, Associate Professor:

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

No agencies please.

Application proces

Step 1 - Apply

Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.

Step 2 - Selection

Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.

Step 3 - Job interview

You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.

Step 4 - Offer and terms of employment

It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.

Step 5 - Getting started

Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!

Contact me

Jerry Chandansingh

Jerry Chandansingh
Erasmus MC

Pioneering, pushing boundaries and leading: in healthcare, education and research

Erasmus MC is an international leading academic hospital in Rotterdam. We are recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them. We have access to the latest equipment and techniques. A working environment that gets the best out of people.

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